Welcome to the AHS 2020 ePoster Session. Please scroll down to view all of the submitted posters or press Control-F to search. To view the poster and its abstract, click on the poster image. Many posters also have a brief audio introduction which can be played by going to the bottom of the poster screen.
P036: DEVELOPMENT OF A NOVEL SYNTHETIC RESORBABLE HERNIA MESH IN A PORCINE MODEL
Neesha S Patel; Shiixuan Chen; Jingwei Xie; Mark A Carlson; University of Nebraska Medical Center
During repair of complicated abdominal wall defects, biologic mesh is commonly used in clinical situations that require a resorbable material. While biologic mesh is useful in these circumstances, it is expensive ($30-50 per cm2, or >100-fold the cost of synthetic nonresorbable mesh). Our objective has been to develop a relatively low-cost, synthetic, resorbable hernia mesh which would be a cheaper alternative to biologic mesh; we now report some preliminary data from this ongoing project. Mesh prototype 1 (N = 4 subjects) was a bilaminar construct with an anti-adhesive layer integrated with pro-adhesive layer, electrospun from FDA-approved synthetic resorbable polymers. Mesh prototype 2 (N = 4) was similar except with a layer of macroporous lightweight polypropylene sandwiched between the two resorbable layers. A 10 x 10 cm sheet of each mesh was placed intraperitoneally through a midline incision in 3 mo old domestic swine, anchoring at the margin with polypropylene sutures, and then midline incision closure. Comparator groups included coated polypropylene mesh (Proceed®; N = 6), porcine small intestinal submucosa (biologic mesh; Biodesign®; N = 5), fascial incision without mesh (N = 5), and skin incision only (N = 5). Pigs were euthanized at 90 days. Starting pig weight and 3-mo weight gain was not different among groups. Final mesh area for the prototype mesh 1, 2, and Proceed® was 78.3 +/- 5.3, 86.9 +/- 9.2, and 72.2 +/- 3.8 cm2, respectively, which was marginally different (p = 0.041, ANOVA). Final mesh area was difficult to quantify for Biodesign® secondary to resorption. Adhesion scores among the six groups were not statistically significant, reflecting minimal omental adhesions to the midline. Final serum testing (CBC, CMP, ESR, CRP) and organ necropsy weights were not different among the six groups. Histologic and tensiometric analyses are pending at this submission. The performance of the synthetic resorbable prototype meshes in gross evaluations was comparable to commercially-available synthetic non-resorbable and biologic comparators. There were no signs of systemic toxicity. All meshes displayed some shrinkage after 3 mo of implantation. Visceral adhesion to mesh was not a problematic outcome in this model.
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